Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tnnt2  troponin T2, cardiac   (Synonyms: cardiac TnT, cTnT, Tnt)
Results	Reference
1	J:266263 Andersen P, Tampakakis E, Jimenez DV, Kannan S, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Chelko SP, Kwon C, Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018 Aug 7;9(1):3140
1	J:328231 Astanina E, Doronzo G, Cora D, Neri F, Oliviero S, Genova T, Mussano F, Middonti E, Vallariello E, Cencioni C, Valdembri D, Serini G, Limana F, Foglio E, Ballabio A, Bussolino F, The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells. Nat Commun. 2022 Sep 3;13(1):5191
1	J:338901 Boogerd CJ, Perini I, Kyriakopoulou E, Han SJ, La P, van der Swaan B, Berkhout JB, Versteeg D, Monshouwer-Kloots J, van Rooij E, Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023 Aug 5;14(1):4716
1	J:137459 Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM, A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 3;454(7200):104-8
1	J:213298 Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang DZ, mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013 Jun 7;112(12):1557-66
1	J:131962 Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ, Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2111-6
1	J:314168 Chen W, Liu X, Li W, Shen H, Zeng Z, Yin K, Priest JR, Zhou Z, Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during development. EMBO Rep. 2021 Nov 4;22(11):e52389
1	J:336417 Chong D, Gu Y, Zhang T, Xu Y, Bu D, Chen Z, Xu N, Li L, Zhu X, Wang H, Li Y, Zheng F, Wang D, Li P, Xu L, Hu Z, Li C, Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
1	J:258209 Chorghade S, Seimetz J, Emmons R, Yang J, Bresson SM, Lisio M, Parise G, Conrad NK, Kalsotra A, Poly(A) tail length regulates PABPC1 expression to tune translation in the heart. Elife. 2017 Jun 27;6:e24139
1	J:343607 Cui M, Bezprozvannaya S, Hao T, Elnwasany A, Szweda LI, Liu N, Bassel-Duby R, Olson EN, Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development. Dev Cell. 2023 Dec 18;58(24):2867-2880.e7
1	J:181488 Delgado-Olguin P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG, Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012;44(3):343-7
1	J:332240 Feng W, Bais A, He H, Rios C, Jiang S, Xu J, Chang C, Kostka D, Li G, Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages. Nat Commun. 2022 Dec 27;13(1):7960
1	J:324468 Gan P, Wang Z, Morales MG, Zhang Y, Bassel-Duby R, Liu N, Olson EN, RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development. Dev Cell. 2022 Apr 25;57(8):959-973.e7
1	J:290729 Grundl M, Walz S, Hauf L, Schwab M, Werner KM, Spahr S, Schulte C, Maric HM, Ade CP, Gaubatz S, Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. PLoS Genet. 2020 May;16(5):e1008818
1	J:342844 Harvey AB, Wolters RA, Deepe RN, Tarolli HG, Drummond JR, Trouten A, Zandi A, Barth JL, Mukherjee R, Romeo MJ, Vaena SG, Tao G, Muise-Helmericks R, Ramos PS, Norris RA, Wessels A, Epicardial deletion of Sox9 leads to myxomatous valve degeneration and identifies Cd109 as a novel gene associated with valve development. J Mol Cell Cardiol. 2023 Nov 5;186:16-30
1*	J:257896 Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY, Wang Y, Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018 Feb 16;9(1):700
1	J:342551 Kim EE, Shekhar A, Ramachandran J, Khodadadi-Jamayran A, Liu FY, Zhang J, Fishman GI, The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation. Development. 2023 Nov 1;150(21)
1	J:312381 Li M, Zheng H, Han Y, Chen Y, Li B, Chen G, Chen X, Huang S, He X, Wei G, Xu T, Feng X, Liao W, Liao Y, Chen Y, Bin J, LncRNA Snhg1-driven self-reinforcing regulatory network promoted cardiac regeneration and repair after myocardial infarction. Theranostics. 2021;11(19):9397-9414
1	J:344312 Liu H, Zhou R, Li S, Dong J, Fang Y, Luo Y, Su H, Lai B, Liang L, Zhang D, Zhang Y, Shyy JY, Zhou B, Yuan Z, Wang Y, Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722
1	J:236318 Ma H, Yin C, Zhang Y, Qian L, Liu J, ErbB2 is required for cardiomyocyte proliferation in murine neonatal hearts. Gene. 2016 Nov 5;592(2):325-30
1	J:138923 Manuylov NL, Manuylova E, Avdoshina V, Tevosian S, Serdin1/Lrrc10 is dispensable for mouse development. Genesis. 2008 Sep 9;46(9):441-446
1	J:251385 Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK, Sall1 transiently marks undifferentiated heart precursors and regulates their fate. J Mol Cell Cardiol. 2016 Mar;92:158-62
1*	J:272568 Munoz-Martin N, Sierra R, Schimmang T, Villa Del Campo C, Torres M, Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition. Development. 2019 Feb 1;146(3):dev170753
1	J:225772 Murray TV, Smyrnias I, Schnelle M, Mistry RK, Zhang M, Beretta M, Martin D, Anilkumar N, de Silva SM, Shah AM, Brewer AC, Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription. J Mol Cell Cardiol. 2015 Feb;79:54-68
1	J:246542 Nakashima Y, Yanez DA, Touma M, Nakano H, Jaroszewicz A, Jordan MC, Pellegrini M, Roos KP, Nakano A, Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system. Circ Res. 2014 Mar 28;114(7):1103-13
1*	J:207639 Nelson DO, Jin DX, Downs KM, Kamp TJ, Lyons GE, Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development. Dev Dyn. 2014 Mar;243(3):381-92
1	J:326253 Ni L, Lin B, Hu L, Zhang R, Fu F, Shen M, Yang J, Shi D, Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1. J Am Heart Assoc. 2022 Jun 7;11(11):e024854
1*	J:180809 Ola R, Lefebvre S, Braunewell KH, Sainio K, Sariola H, The expression of Visinin-like 1 during mouse embryonic development. Gene Expr Patterns. 2012 Jan;12(1-2):53-62
1	J:289859 Ortiz-Sanchez P, Villalba-Orero M, Lopez-Olaneta MM, Larrasa-Alonso J, Sanchez-Cabo F, Marti-Gomez C, Camafeita E, Gomez-Salinero JM, Ramos-Hernandez L, Nielsen PJ, Vazquez J, Muller-McNicoll M, Garcia-Pavia P, Lara-Pezzi E, Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction. Circ Res. 2019 Jul 5;125(2):170-183
1	J:204551 Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K, Mueller E, Li H, Lee BC, Lee SB, A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell. 2013 Aug 26;26(4):393-404
1*	J:276621 Semmler J, Kormann J, Srinivasan SP, Koster A, Salzer D, Reppel M, Hescheler J, Plomann M, Nguemo F, Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. Pharmacol Res. 2018 Feb;128:200-210
1	J:346121 Shu J, Yan S, Ju C, Chen L, Liang M, Wang C, Huang K, PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int J Biol Sci. 2024;20(5):1602-1616
1*	J:244087 Stopp S, Grundl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S, Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034
1	J:316473 Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C, Heart neurons use clock genes to control myocyte proliferation. Sci Adv. 2021 Dec 3;7(49):eabh4181
1	J:284528 Tang W, Martik ML, Li Y, Bronner ME, Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish. Elife. 2019 Aug 8;8:e47929
1	J:154033 Torres R, Ramirez JC, A chemokine targets the nucleus: Cxcl12-gamma isoform localizes to the nucleolus in adult mouse heart. PLoS One. 2009;4(10):e7570
1	J:285937 Volland C, Schott P, Didie M, Manner J, Unsold B, Toischer K, Schmidt C, Urlaub H, Nickels K, Knoll R, Schmidt A, Guan K, Hasenfuss G, Seidler T, Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival. Cardiovasc Res. 2020 Mar 1;116(3):592-604
1	J:176107 Walsh S, Ponten A, Fleischmann BK, Jovinge S, Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei. Cardiovasc Res. 2010 Jun 1;86(3):365-73
1*	J:52598 Wang DZ, Reiter RS, Lin JL, Wang Q, Williams HS, Krob SL, Schultheiss TM, Evans S, Lin JJ, Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999 Mar;126(6):1281-94
1*	J:175398 Wei TC, Lin HY, Lu CC, Chen CM, You LR, Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene Expr Patterns. 2011 Oct;11(7):384-94
1	J:307415 Xing S, Tian JZ, Yang SH, Huang XT, Ding YF, Lu QY, Yang JS, Yang WJ, Setd4 controlled quiescent c-Kit(+) cells contribute to cardiac neovascularization of capillaries beyond activation. Sci Rep. 2021 Jun 2;11(1):11603
1	J:253740 Yan J, Zhang L, Sultana N, Oh JG, Wu B, Hajjar RJ, Zhou B, Cai CL, A series of robust genetic indicators for definitive identification of cardiomyocytes. J Mol Cell Cardiol. 2016 Aug;97:278-85
1	J:344873 Yang Y, Wang X, Tan Y, Xu Y, Guo X, Wu Y, Wang W, Jing R, Zhu F, Ye D, Zhang Q, Lu C, Kang J, Wang G, LncCMRR Plays an Important Role in Cardiac Differentiation by Regulating the Purb/Flk1 Axis. Stem Cells. 2023 Jan 30;41(1):11-25
1*	J:216780 Zafiriou MP, Noack C, Unsold B, Didie M, Pavlova E, Fischer HJ, Reichardt HM, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayan LC, Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells. 2014 Sep;32(9):2480-91
1	J:311867 Zhang X, Wang Z, Xu Q, Chen Y, Liu W, Zhong T, Li H, Quan C, Zhang L, Cui CP, Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium. iScience. 2021 Oct 22;24(10):103097
1	J:289319 Zhang Y, Zhang C, Zhang H, Zeng W, Li S, Chen C, Song X, Sun J, Sun Z, Cui C, Cao X, Zheng L, Wang P, Zhao W, Zhang Z, Xu Y, Zhu M, Chen H, ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury. FASEB J. 2019 Aug;33(8):9062-9074
1*	J:268201 Zhang Z, Nam YJ, Generation of MLC-2v-tdTomato knock-in reporter mouse line. Genesis. 2018 Oct;56(10):e23256
1	J:279072 Zhang Z, Zhang Q, Lal H, Nam YJ, Generation of Nppa-tagBFP reporter knock-in mouse line for studying cardiac chamber specification. Genesis. 2019 Jun;57(6):e23294
1	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147
1	J:261328 Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H, Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110